Glycosylated synaptomatrix regulation of trans-synaptic signaling
نویسندگان
چکیده
منابع مشابه
N-glycosylation requirements in neuromuscular synaptogenesis.
Neural development requires N-glycosylation regulation of intercellular signaling, but the requirements in synaptogenesis have not been well tested. All complex and hybrid N-glycosylation requires MGAT1 (UDP-GlcNAc:α-3-D-mannoside-β1,2-N-acetylglucosaminyl-transferase I) function, and Mgat1 nulls are the most compromised N-glycosylation condition that survive long enough to permit synaptogenesi...
متن کاملSynaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
Normal brain function requires that the overall synaptic activity in neural circuits be kept constant. Long-term alterations of neural activity lead to homeostatic regulation of synaptic strength by a process known as synaptic scaling. The molecular mechanisms underlying synaptic scaling are largely unknown. Here, we report that all-trans retinoic acid (RA), a well-known developmental morphogen...
متن کاملRegulation of postsynaptic signaling in structural synaptic plasticity.
Morphological changes of dendritic spines are strongly associated with synaptic development and synaptic plasticity, which underlies learning and memory. These changes are driven by alterations of F-actin dynamics under the control of Rho GTPases or by synaptic trafficking and insertion of glutamate receptors. Understanding the molecular events that occur during the formation and stabilization ...
متن کاملRegulation of NMDA-receptor synaptic transmission by Wnt signaling.
Wnt ligands are secreted glycoproteins controlling gene expression and cytoskeleton reorganization involved in embryonic development of the nervous system. However, their role in later stages of brain development, particularly in the regulation of established synaptic connections, is not known. We found that Wnt-5a acutely and specifically upregulates synaptic NMDAR currents in rat hippocampal ...
متن کاملRegulation of cpg15 by signaling pathways that mediate synaptic plasticity.
Transcriptional activation is a key link between neuronal activity and long-term synaptic plasticity. Little is known about genes responding to this activation whose products directly effect functional and structural changes at the synapse. cpg15 is an activity-regulated gene encoding a membrane-bound ligand that regulates dendritic and axonal arbor growth and synaptic maturation. We report tha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2011
ISSN: 1932-8451
DOI: 10.1002/dneu.20891